Watch people for signs of respiratory melancholy Which may be greater than in any other case predicted and reduce the dosage of DILAUDID INJECTION and/or maybe the muscle mass relaxant as essential.
Hydromorphone is understood to become substantially excreted via the kidney, and the chance of adverse reactions to this drug can be increased in patients with impaired renal function.
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In these sufferers, mixed agonist/antagonist and partial agonist analgesics may perhaps decrease the analgesic outcome and/or precipitate withdrawal indications [see DRUG INTERACTIONS].
an erection that will not disappear (priapism). For those who have an erection that lasts much more than four hours, get health care support right away. If It isn't treated at once, priapism can forever destruction your penis.
In case the affected person develops these indications or symptoms, increase the dose towards the former degree and taper far more slowly and gradually, both by rising the interval among decreases, lowering the amount of change in dose, or both of those. Will not abruptly discontinue DILAUDID INJECTION within a bodily-dependent affected individual [see WARNINGS AND PRECAUTIONS, Drug Abuse And Dependence].
Notice newborns for signs of neonatal opioid withdrawal syndrome and deal with appropriately. Advise pregnant Ladies using opioids for an extended length of time of the chance of neonatal opioid withdrawal syndrome and ensure that management by neonatology gurus will probably be readily available at delivery [see Use In Distinct Populations].
A lot of leads to, from pressure towards the flu to specified Serious diseases could potentially cause body aches. Study what could be leading to your signs and symptoms.
Medical Considerations Monitor infants exposed to DILAUDID INJECTION through breast milk for excess sedation and respiratory depression. Withdrawal indicators can arise in breastfed infants when maternal administration of hydromorphone is stopped, or when breast-feeding is stopped.
Inspect parenteral drug products visually for particulate make any difference and discoloration before administration, Any time solution and container permit. A slight yellowish discoloration may well create in DILAUDID INJECTION.
Carcinogenesis Long-term studies in animals To judge the carcinogenic probable of hydromorphone have not been executed.
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In a person physically dependent on opioids, administration from the advisable standard dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity from the withdrawal indicators seasoned will rely upon the degree of physical dependence and also the dose from the antagonist administered.